Husband of Mary Lamb Orsino and father of three sons: Frank Orzino of Ithaca, Anthony Orzino of Mass, Querino (Ortz) Orzino Jr. of Ithaca, and five daughters: Angie Pirko of Ithaca, Mary Scaia of Alliance, Ohio, Clara Leonardo of Ithaca, Louise Sisson of Lansing, and Ann Otto of Ithaca.

Obituary of Querino Orsini, Ithaca Journal, October 3, 1989, 4.